TocilizumabV1, Main, Exploration, bibRecord, 002884

A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid

Identifieur interne : 002884 ( Main/Exploration ); précédent : 002883; suivant : 002885

A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid

Auteurs : Naoko Takeuchi [Japon] ; Toru Arai [Japon] ; Masanori Kitaichi [Japon] ; Yoshikazu Inoue [Japon]

Source :

BMJ Case Reports [ 1757-790X ] ; 2013-09-26.

RBID : ISTEX:06D33D687921E723E77E570AC63D390FE78EAA95

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Anticorps monoclonaux humanisés (usage thérapeutique), Association de médicaments, Biopsie, Diagnostic différentiel, Glucocorticoïdes (usage thérapeutique), Granulome (), Granulome (diagnostic), Granulome (traitement médicamenteux), Humains, Maladies pulmonaires (), Maladies pulmonaires (diagnostic), Maladies pulmonaires (traitement médicamenteux), Mâle, Noeuds lymphatiques (anatomopathologie), Tomodensitométrie.
MESH :
- anatomopathologie : Noeuds lymphatiques.
- diagnostic : Granulome, Maladies pulmonaires.
- traitement médicamenteux : Granulome, Maladies pulmonaires.
- usage thérapeutique : Anticorps monoclonaux humanisés, Glucocorticoïdes.
- Adulte d'âge moyen, Association de médicaments, Biopsie, Diagnostic différentiel, Granulome, Humains, Maladies pulmonaires, Mâle, Tomodensitométrie.

English descriptors

KwdEn :
- Antibodies, Monoclonal, Humanized (therapeutic use), Biopsy, Castleman Disease (complications), Castleman Disease (diagnosis), Castleman Disease (drug therapy), Diagnosis, Differential, Drug Therapy, Combination, Glucocorticoids (therapeutic use), Granuloma (complications), Granuloma (diagnosis), Granuloma (drug therapy), Humans, Lung Diseases (complications), Lung Diseases (diagnosis), Lung Diseases (drug therapy), Lymph Nodes (pathology), Male, Middle Aged, Tomography, X-Ray Computed.
MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Glucocorticoids.
- complications : Castleman Disease, Granuloma, Lung Diseases.
- diagnosis : Castleman Disease, Granuloma, Lung Diseases.
- drug therapy : Castleman Disease, Granuloma, Lung Diseases.
- pathology : Lymph Nodes.
Teeft :
- Biopsy, Comorbid, Corticosteroid, Diagnosis, Differential, Drug Therapy, Combination, Follicle, Germinal, Germinal centres, Granuloma, Gure, Humanised antihuman receptor, Humans, Hyalinising, Hyalinising granuloma, Hyalinous, Lesion, Lymph, Lymph node, Lymphadenopathy, Lymphoid, Lymphoid cells, Macule, Male, Middle Aged, Multicentric, Multicentric disease, National hospital organization chest, Ndings, Node, Nodular lesion, Nodule, Opacity, Plasma cell type, Plasma cells, Pulmonary hyalinising granuloma, Pulmonary hyalinizing granuloma, Reactive, Reactive protein, Receptor, Sakai, Surgical lung biopsy, Takeuchi, Tocilizumab, Tomography, X-Ray Computed, Weight loss.

Abstract

A 49-year-old man with superficial lymphadenopathy presented with symptoms of low-grade fever, general fatigue and weight loss. On examination, multiple superficial lymphadenopathies and brown macules were observed on the trunk. Laboratory studies revealed an elevation of serum C reactive protein and interleukin 6 (IL-6) in addition to polyclonal hyperimmunoglobulinaemia. High-resolution CT of the chest showed bilateral multiple nodules and patchy ground-glass opacities with interstitial thickening. Biopsy of the cervical lymph node and skin biopsy showed numerous perivascular plasma cells, which were characteristic of the plasma cell type of Castleman's disease. Surgical lung biopsy showed hyalinising granuloma, which are hyalinous nodular lesions surrounded by lymphoid cells. He was diagnosed with multicentric Castleman's disease complicated by pulmonary hyalinising granulomas; his symptoms improved by treatment with tocilizumab, which is a humanised antihuman IL-6 receptor monoclonal antibody and corticosteroid. This is the first report of a comorbid case successfully treated with tocilizumab and corticosteroid.

Url:

https://api.istex.fr/ark:/67375/NVC-TNMNSLJ4-S/fulltext.pdf

DOI: 10.1136/bcr-2013-010233

Affiliations:

Japon

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid</title>
<author><name sortKey="Takeuchi, Naoko" sort="Takeuchi, Naoko" uniqKey="Takeuchi N" first="Naoko" last="Takeuchi">Naoko Takeuchi</name>
</author>
<author><name sortKey="Arai, Toru" sort="Arai, Toru" uniqKey="Arai T" first="Toru" last="Arai">Toru Arai</name>
</author>
<author><name sortKey="Kitaichi, Masanori" sort="Kitaichi, Masanori" uniqKey="Kitaichi M" first="Masanori" last="Kitaichi">Masanori Kitaichi</name>
</author>
<author><name sortKey="Inoue, Yoshikazu" sort="Inoue, Yoshikazu" uniqKey="Inoue Y" first="Yoshikazu" last="Inoue">Yoshikazu Inoue</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:06D33D687921E723E77E570AC63D390FE78EAA95</idno>
<date when="2013" year="2013">2013</date>
<idno type="doi">10.1136/bcr-2013-010233</idno>
<idno type="url">https://api.istex.fr/ark:/67375/NVC-TNMNSLJ4-S/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000508</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000508</idno>
<idno type="wicri:Area/Istex/Curation">000508</idno>
<idno type="wicri:Area/Istex/Checkpoint">000375</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000375</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:24072826</idno>
<idno type="wicri:Area/PubMed/Corpus">001585</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001585</idno>
<idno type="wicri:Area/PubMed/Curation">001585</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001585</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001638</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001638</idno>
<idno type="wicri:Area/Ncbi/Merge">000903</idno>
<idno type="wicri:Area/Ncbi/Curation">000903</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000903</idno>
<idno type="wicri:Area/Main/Merge">002898</idno>
<idno type="wicri:Area/Main/Curation">002884</idno>
<idno type="wicri:Area/Main/Exploration">002884</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid</title>
<author><name sortKey="Takeuchi, Naoko" sort="Takeuchi, Naoko" uniqKey="Takeuchi N" first="Naoko" last="Takeuchi">Naoko Takeuchi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arai, Toru" sort="Arai, Toru" uniqKey="Arai T" first="Toru" last="Arai">Toru Arai</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Respiratory Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kitaichi, Masanori" sort="Kitaichi, Masanori" uniqKey="Kitaichi M" first="Masanori" last="Kitaichi">Masanori Kitaichi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pathology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inoue, Yoshikazu" sort="Inoue, Yoshikazu" uniqKey="Inoue Y" first="Yoshikazu" last="Inoue">Yoshikazu Inoue</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Diffuse Lung Diseases and Respiratory Failure, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">BMJ Case Reports</title>
<title level="j" type="abbrev">BMJ Case Reports</title>
<idno type="eISSN">1757-790X</idno>
<imprint><publisher>BMJ Publishing Group Ltd</publisher>
<date type="published" when="2013-09-26">2013-09-26</date>
<biblScope unit="volume">2013</biblScope>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Biopsy</term>
<term>Castleman Disease (complications)</term>
<term>Castleman Disease (diagnosis)</term>
<term>Castleman Disease (drug therapy)</term>
<term>Diagnosis, Differential</term>
<term>Drug Therapy, Combination</term>
<term>Glucocorticoids (therapeutic use)</term>
<term>Granuloma (complications)</term>
<term>Granuloma (diagnosis)</term>
<term>Granuloma (drug therapy)</term>
<term>Humans</term>
<term>Lung Diseases (complications)</term>
<term>Lung Diseases (diagnosis)</term>
<term>Lung Diseases (drug therapy)</term>
<term>Lymph Nodes (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux humanisés (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Biopsie</term>
<term>Diagnostic différentiel</term>
<term>Glucocorticoïdes (usage thérapeutique)</term>
<term>Granulome ()</term>
<term>Granulome (diagnostic)</term>
<term>Granulome (traitement médicamenteux)</term>
<term>Humains</term>
<term>Maladies pulmonaires ()</term>
<term>Maladies pulmonaires (diagnostic)</term>
<term>Maladies pulmonaires (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Tomodensitométrie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Glucocorticoids</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Noeuds lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Castleman Disease</term>
<term>Granuloma</term>
<term>Lung Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Castleman Disease</term>
<term>Granuloma</term>
<term>Lung Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Granulome</term>
<term>Maladies pulmonaires</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Castleman Disease</term>
<term>Granuloma</term>
<term>Lung Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Granulome</term>
<term>Maladies pulmonaires</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Glucocorticoïdes</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Biopsy</term>
<term>Comorbid</term>
<term>Corticosteroid</term>
<term>Diagnosis, Differential</term>
<term>Drug Therapy, Combination</term>
<term>Follicle</term>
<term>Germinal</term>
<term>Germinal centres</term>
<term>Granuloma</term>
<term>Gure</term>
<term>Humanised antihuman receptor</term>
<term>Humans</term>
<term>Hyalinising</term>
<term>Hyalinising granuloma</term>
<term>Hyalinous</term>
<term>Lesion</term>
<term>Lymph</term>
<term>Lymph node</term>
<term>Lymphadenopathy</term>
<term>Lymphoid</term>
<term>Lymphoid cells</term>
<term>Macule</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multicentric</term>
<term>Multicentric disease</term>
<term>National hospital organization chest</term>
<term>Ndings</term>
<term>Node</term>
<term>Nodular lesion</term>
<term>Nodule</term>
<term>Opacity</term>
<term>Plasma cell type</term>
<term>Plasma cells</term>
<term>Pulmonary hyalinising granuloma</term>
<term>Pulmonary hyalinizing granuloma</term>
<term>Reactive</term>
<term>Reactive protein</term>
<term>Receptor</term>
<term>Sakai</term>
<term>Surgical lung biopsy</term>
<term>Takeuchi</term>
<term>Tocilizumab</term>
<term>Tomography, X-Ray Computed</term>
<term>Weight loss</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Association de médicaments</term>
<term>Biopsie</term>
<term>Diagnostic différentiel</term>
<term>Granulome</term>
<term>Humains</term>
<term>Maladies pulmonaires</term>
<term>Mâle</term>
<term>Tomodensitométrie</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">A 49-year-old man with superficial lymphadenopathy presented with symptoms of low-grade fever, general fatigue and weight loss. On examination, multiple superficial lymphadenopathies and brown macules were observed on the trunk. Laboratory studies revealed an elevation of serum C reactive protein and interleukin 6 (IL-6) in addition to polyclonal hyperimmunoglobulinaemia. High-resolution CT of the chest showed bilateral multiple nodules and patchy ground-glass opacities with interstitial thickening. Biopsy of the cervical lymph node and skin biopsy showed numerous perivascular plasma cells, which were characteristic of the plasma cell type of Castleman's disease. Surgical lung biopsy showed hyalinising granuloma, which are hyalinous nodular lesions surrounded by lymphoid cells. He was diagnosed with multicentric Castleman's disease complicated by pulmonary hyalinising granulomas; his symptoms improved by treatment with tocilizumab, which is a humanised antihuman IL-6 receptor monoclonal antibody and corticosteroid. This is the first report of a comorbid case successfully treated with tocilizumab and corticosteroid.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Takeuchi, Naoko" sort="Takeuchi, Naoko" uniqKey="Takeuchi N" first="Naoko" last="Takeuchi">Naoko Takeuchi</name>
</noRegion>
<name sortKey="Arai, Toru" sort="Arai, Toru" uniqKey="Arai T" first="Toru" last="Arai">Toru Arai</name>
<name sortKey="Inoue, Yoshikazu" sort="Inoue, Yoshikazu" uniqKey="Inoue Y" first="Yoshikazu" last="Inoue">Yoshikazu Inoue</name>
<name sortKey="Kitaichi, Masanori" sort="Kitaichi, Masanori" uniqKey="Kitaichi M" first="Masanori" last="Kitaichi">Masanori Kitaichi</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/TocilizumabV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002884 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002884 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    TocilizumabV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:06D33D687921E723E77E570AC63D390FE78EAA95
   |texte=   A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid
}}

This area was generated with Dilib version V0.6.34.
Data generation: Fri May 22 09:34:00 2020. Site generation: Sun Mar 28 09:01:19 2021

Serveur d'exploration Tocilizumab

A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid

A comorbid case of multicentric Castleman's disease and pulmonary hyalinising granuloma successfully treated with tocilizumab and corticosteroid

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration Tocilizumab
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.